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Immune Globulin Product Comparison


Brand Name
Concentration
pH
Initial Rate
Max Rate
IgA Content
(mcg/mL)
Osmolarity/Osmolality
(mOsmol/kg)
Comments
IV
SubQa
IVb
SubQa
Bivigam
10%
4 to 4.6
0.3 mL/kg/hour
3.6 mL/kg/hour
≤200
Not available
Contains polysorbate 80
Carimune NFc
3%
6.4 to 6.8
1 mL/kg/hour
6 mL/kg/hour
Traced
192 to 498e
Contains sucrose
12%
0.24 mL/kg/hour
1.5 mL/kg/hour
768 to 1,074e
Flebogamma DIF
5%
5 to 6
0.6 mL/kg/hour
6 mL/kg/hour
<50
240 to 370
10%
0.6 mL/kg/hour
4.8 mL/kg/hour
<100
GamaSTAN S/D
15% to 18%
6.4 to 7.2
Not available
Not available
For IM use
Gammagard S/D
5%
6.4 to 7.2
0.5 mL/kg/hour
4 mL/kg/hour
≤1f
636
Contains polysorbate 80
10%
0.5 mL/kg/hour
8 mL/kg/hour
≤2f
1,250
Gammagard Liquid
10%
4.6 to 5.1
0.5 mL/kg/hour
<40 kg: 15 mL/hour/site with a maximum of 8 sites
≥40 kg: 20 mL/hour/site with a maximum of 8 sites
5 mL/kg/hour
5.4 mL/kg/hour (MMN only)
<40 kg: 20 mL/hour/site with a maximum of 8 sites; maximum total rate: 160 mL/hour
≥40 kg: 30 mL/h/site with a maximum of 8 sites; maximum total rate: 240 mL/hour
37
240 to 300
Gammaked
10%
4 to 4.5
0.6 mL/kg/hour
1.2 mL/kg/hour (CIDP only)
20 mL/hour/site with a maximum of 8 sites
4.8 mL/kg/hour
Not determined
46
258
Gammaplex
5%
4.8 to 5
0.6 mL/kg/hour
4.8 mL/kg/hour
<10
420 to 500
Contains polysorbate 80
Gamunex-C
10%
4 to 4.5
0.6 mL/kg/hour
1.2 mL/kg/hour (CIDP only)
20 mL/hour/site with a maximum of 8 sites
4.8 mL/kg/hour
Not determined
46
258
Hizentra
20%
4.6 to 5.2
15 mL/hour/site with a maximum of 4 sites
Up to 25 mL/hour/site with a maximum of 4 sites; maximum total rate: 50 mL/hour
≤50
380
Contains L-proline and polysorbate 80
HyQvia
10%
4.6 to 5.1
First 2 infusions:
<40 kg: 5 mL/hour for 5 to 15 minutes; 10 mL/hour for 5 to 15 minutes; 20 mL/hour for 5 to 15 minutes; 40 mL/hour for 5 to 15 minutes; then 80 mL/hour for remainder of infusion
≥40 kg: 10 mL/hour for 5 to 15 minutes; 30 mL/hour for 5 to 15 minutes; 60 mL/hour for 5 to 15 minutes; 120 mL/hour for 5 to 15 minutes; then 240 mL/hour for remainder of infusion
Next 2 or 3 infusions:
<40 kg: 10 mL/hour for 5 to 15 minutes; 20 mL/hour for 5 to 15 minutes; 40 mL/hour for 5 to 15 minutes; 80 mL/hour for 5 to 15 minutes; then 160 mL/hour for remainder of infusion
≥40 kg: 10 mL/hour for 5 to 15 minutes; 30 mL/hour for 5 to 15 minutes; 120 mL/hour for 5 to 15 minutes; 240 mL/hour for 5 to 15 minutes; then 300 mL/hour for remainder of infusion
<40 kg: 160 mL/hour
≥40 kg: 300 mL/hour
37
240 to 300
Supplied with hyaluronidase (human recombinant)
Octagam
5%
5.1 to 6
0.6 mL/kg/hour
4 mL/kg/hour
≤200
310 to 380
Contains maltose
Octagam
10%
4.5 to 5
0.6 mL/kg/hour
7.2 mL/kg/hour
106
310 to 380
Sucrose-free
Privigen
10%
4.6 to 5
0.3 mL/kg/hour
2.4 mL/kg/hour (ITP)
4.8 mL/kg/hour
≤25
240 to 440
Contains L-proline
CIDP = chronic inflammatory demyelinating polyneuropathy, ITP = immune thrombocytopenia (formerly known as idiopathic thrombocytopenic purpura), MMN = multifocal motor neuropathy
aSubcutaneous administration only for the treatment of primary humoral immunodeficiency (PI)
bLower infusion rates should be used in patients at risk for renal dysfunction or thrombotic complications; see specific product information for details.
cOther concentrations may be prepared; see product information for additional details.
dPer product information; other sources list IgA content as 1,000 to 2,000 mcg/mL for 6% solution (Siegel J. Immune globulins: therapeutic, pharmaceutical, cost, and administration considerations. Pharm Prac News. 2013).
eOsmolarity depends on concentration and diluent used; see product information for details.
fData presented is based on the maximum concentration that can be prepared. The 5% solution with IgA content <2.2 mcg/mL has been discontinued. The lower IgA product (ie, IgA <1 mcg/mL for the 5% prepared solution) is available by special request; contact manufacturer or see specific product information for details.

Lexi-Comp, Inc. (Pediatric & Neonatal Lexi-Drugs®). Lexi-Comp, Inc.; January 25, 2018.