Based on an ongoing and systematic analysis of all available evidence by CredibleMeds' Scientific Review Board, CredibleMeds® places drugs into broad categories based on whether each can cause QT prolongation or TdP. Because these actions are highly dependent on the circumstances of each drug’s use AND each patient’s clinical characteristics, this is not an attempt to rank-order the drugs within each category. Therefore, it is not recommend that these lists be used to rank-order the drugs for their relative toxicity.
Known Risk of TdP
These drugs prolong the QT interval AND are clearly associated with a known risk of TdP, even when taken as recommended.
Possible Risk of TdP
These drugs can cause QT prolongation BUT currently lack evidence for a risk of TdP when taken as recommended.
Conditional Risk of TdP
These drugs are associated with TdP BUT only under certain conditions of their use (e.g. excessive dose, in patients with conditions such as hypokalemia, or when taken with interacting drugs) OR by creating conditions that facilitate or induce TdP (e.g. by inhibiting metabolism of a QT-prolonging drug or by causing an electrolyte disturbance that induces TdP.)
Drugs to Avoid in Congenital Long QT
These drugs pose a high risk of TdP for patients with CLQTS and include all those in the above three categories (KR, PR & CR) PLUS additional drugs that do not prolong the QT interval per se but which have a Special Risk (SR) because of their other actions.
Generic Name
|
Brand Names (Partial List)
|
Drug Class
|
Therapeutic Use
|
PubMed Search
|
Risk Category
|
|---|---|---|---|---|---|
| Albuterol (salbutamol) | Proventil, Ventolin, Ventolin-HFA, Accuneb, Combivent, Vospire-ER, ProAir HFA, Duoneb | Bronchodilator | Asthma | LINK | |
| Alfuzosin | Uroxatral | Alpha1-blocker | Benign prostatic hyperplasia | LINK | |
| Amantadine | Symmetrel, Symadine | Antiviral | Viral infection (Influenza), Parkinson's disease | LINK | |
| Amiodarone | Cordarone, Pacerone, Nexterone | Antiarrhythmic | Abnormal heart rhythm | LINK | |
| Amisulpride (Only on Non US Market) | Solian, Supitac, Soltus, Amitrex, Amazeo | Antipsychotic, atypical | Schizophrenia | LINK | |
| Amitriptyline | Elavil (Discontinued 6/13), Tryptomer, Tryptizol, Laroxyl, Saroten, Sarotex Lentizol, Endep | Antidepressant, Tricyclic | Depression | LINK | |
| Amphetamine (Amfetamine) | Adderal-XR, Dexedrine, Dextroamp | CNS stimulant | ADHD | LINK | |
| Amphotericin B | Fungilin, Fungizone, Abelcet, AmBisome, Fungisome, Amphocil, Amphotec | Antifungal | Fungal infection | LINK | |
| Anagrelide | Agrylin, Xagrid | Phosphodiesterase 3 inhibitor | Thrombocythemia | LINK | |
| Apomorphine | Apokyn, Ixense, Spontane, Uprima | Dopamine agonist | Parkinson's disease | LINK | |
| Arformoterol | Brovana | Bronchodilator | Bronchoconstriction in COPD | LINK | |
| Aripiprazole | Abilify, Aripiprex | Antipsychotic, atypical | Schizophrenia, depression (adjunct) | LINK | |
| Arsenic trioxide | Trisenox | Anticancer | Cancer (leukemia) | LINK | |
| Artenimol+piperaquine (Only on Non US Market) | Eurartesim | Antimalarial | Malaria | LINK | |
| Asenapine | Saphris, Sycrest | Antipsychotic, atypical | Schizophrenia | LINK | |
| Astemizole (Removed from Market) | Hismanal | Antihistamine | Allergic rhinitis | LINK | |
| Atazanavir | Reyataz, Evotaz | Antiviral | Viral infection (HIV/AIDS) | LINK | |
| Atomoxetine | Strattera | Norepinephrine reuptake inhibitor | ADHD | LINK | |
| Azithromycin | Zithromax, Zmax | Antibiotic | Bacterial infection | LINK | |
| Bedaquiline | Sirturo | Antibiotic | Tuberculosis, Multi-drug resistant | LINK | |
| Bendamustine | Treanda, Treakisym, Ribomustin, Levact | Alkylating agent | Leukemia, lymphoma | LINK | |
| Bendroflumethiazide or bendrofluazide (Only on Non US Market) | Aprinox | Diuretic, thiazide | Hypertension, diuresis | LINK | |
| Benperidol (Only on Non US Market) | Anquil, Glianimon | Anti-psychotic | Antipsychotic | LINK | |
| Bepridil (Removed from Market) | Vascor | Antianginal | Angina Pectoris (heart pain) | LINK | |
| Betrixaban | Bevyxxa | Anticoagulant | Anticoagulant | LINK | |
| Bortezomib | Velcade, Bortecad | Proteasome inhibitor | Cancer (multiple myeloma,lymphoma) | LINK | |
| Bosutinib | Bosulif | Tyrosine kinase inhibitor | Cancer (leukemia) | LINK | |
| Buprenorphine | Butrans, Belbuca, Bunavail, Buprenex, Suboxone, Zubsolv | Opioid receptor modulator | Narcotic addiction and pain | LINK | |
| Cabozantinib | Cometriq | Anti-cancer | Renal cell carcinoma | LINK | |
| Capecitabine | Xeloda | Anticancer | Cancer (GI, Breast) | LINK | |
| Ceritinib | Zykadia | Kinase inhibitor | Cancer (Lung) | LINK | |
| Chloral hydrate | Aquachloral, Novo-Chlorhydrate, Somnos, Noctec, Somnote | Sedative | Sedation, insomnia | LINK | |
| Chloroquine | Aralen | Antimalarial | Malaria | LINK | |
| Chlorpromazine | Thorazine, Largactil, Megaphen | Antipsychotic / Antiemetic | Schizophrenia, nausea, many others | LINK | |
| Cilostazol | Pletal | Phosphodiesterase 3 inhibitor | Intermittent claudication | LINK | |
| Ciprofloxacin | Cipro, Cipro-XR, Neofloxin | Antibiotic | Bacterial infection | LINK | |
| Cisapride (Removed from Market) | Propulsid | GI stimulant | Increase GI motility | LINK | |
| Citalopram | Celexa, Cipramil | Antidepressant, SSRI | Depression | LINK | |
| Clarithromycin | Biaxin, Prevpac | Antibiotic | Bacterial infection | LINK | |
| Clofazimine (Only on Non US Market) | Lamprene | Antimycobacterial | Leprosy | LINK | |
| Clomipramine | Anafranil | Antidepressant, Tricyclic | Depression | LINK | |
| Clozapine | Clozaril, Fazaclo, Versacloz | Antipsychotic, atypical | Schizophrenia | LINK | |
| Cocaine | Cocaine | Local anesthetic | Anesthesia (topical) | LINK | |
| Crizotinib | Xalkori | Kinase inhibitor | Cancer (Non-small cell lung cancer, metastatic) | LINK | |
| Cyamemazine (cyamepromazine) (Only on Non US Market) | Tercian | Antipsychotic | Schizophrenia, sedation | LINK | |
| Dabrafenib | Tafinlar | Kinase inhibitor | Cancer (melanoma) | LINK | |
| Dasatinib | Sprycel | Tyrosine kinase inhibitor | Cancer (leukemia) | LINK | |
| Degarelix | Firmagon, Ferring | Gonadotropin Releasing Hormone Agonist/antagonist | Cancer (prostate) | LINK | |
| Delamanid (Only on Non US Market) | Deltyba | Antibiotic | Tuberculosis, drug resistant | LINK | |
| Desipramine | Pertofrane, Norpramine | Antidepressant, Tricyclic | Depression | LINK | |
| Deutetrabenazine | Austedo | Vesicular monamine transporter 2 inhibitor | Chorea (Huntington's disease | LINK | |
| Dexmedetomidine | Precedex, Dexdor, Dexdomitor | Sedative | Sedation | LINK | |
| Dexmethylphenidate | Focalin, Focalin-XR, Attenade | CNS stimulant | ADHD | LINK | |
| Dextroamphetamine (Dexamfetamine) | Dexedrine, dexamphetamine, dexamfetamine, (S)-(+)-amphetamine, Dextrostat, Dexedrine, Metamina, Attentin, Zenzedi, Procentra, Amfexa | CNS stimulant | ADHD, obesity | LINK | |
| Diphenhydramine | Benadryl, Nytol, Unisom, Sominex, Dimedrol, Daedalon | Antihistamine | Allergic rhinitis, insomnia | LINK | |
| Disopyramide | Norpace | Antiarrhythmic | Abnormal heart rhythm | LINK | |
| Dobutamine | Dobutrex | Inotrope | Heart failure, shock (low blood pressure) | LINK | |
| Dofetilide | Tikosyn | Antiarrhythmic | Abnormal heart rhythm | LINK | |
| Dolasetron | Anzemet | Antiemetic | Nausea, vomiting | LINK | |
| Domperidone (Only on Non US Market) | Motilium, Motillium, Motinorm Costi, Nomit | Antinausea | Nausea, vomiting | LINK | |
| Donepezil | Aricept | Cholinesterase inhibitor | Dementia (Alzheimer's Disease) | LINK | |
| Dopamine | Intropine | Inotrope | Heart failure, shock (low blood pressure) | LINK | |
| Doxepin | Sinequan, Silenor, Aponal, Adapine, Doxal, Deptran, Sinquan | Antidepressant, Tricyclic | Depression | LINK | |
| Dronedarone | Multaq | Antiarrhythmic | Abnormal heart rhythm | LINK | |
| Droperidol | Inapsine, Droleptan, Dridol, Xomolix | Antipsychotic / Antiemetic | Anesthesia (adjunct), nausea | LINK | |
| Droxidopa | Northera | Adrenergic pro-drug | Neurogenic orthostatic hypotension | LINK | |
| Efavirenz | Sustiva and others | Antiretroviral | HIV | LINK | |
| Eliglustat | Cerdelga | Glucosylceramide synthase inhibitor | Gaucher's disease | LINK | |
| Ephedrine | Rynatuss, Broncholate | Bronchodilator, decongestant | Allergic reaction, allergic rhinitis, asthma | LINK | |
| Epinephrine (adrenaline) | Primatene, Bronkaid | Catecholamine, vasoconstrictor | Allergic reaction, anaphylaxis, cardiac arrest | LINK | |
| Epirubicin | Ellence, Pharmorubicin, Epirubicin Ebewe | Anti-cancer | Cancer | LINK | |
| Eribulin mesylate | Halaven | Microtubule inhibitor | Cancer (breast, metastatic) | LINK | |
| Erythromycin | E.E.S., Robimycin, EMycin, Erymax, Ery-Tab, Eryc Ranbaxy, Erypar, Eryped, Erythrocin Stearate Filmtab, Erythrocot, E-Base, Erythroped, Ilosone, MY-E, Pediamycin, Abboticin, Abboticin-ES, Erycin, PCE Dispertab, Stiemycine, Acnasol, Tiloryth | Antibiotic | Bacterial infection, increase GI motility | LINK | |
| Escitalopram | Cipralex, Lexapro, Nexito, Anxiset-E (India), Exodus (Brazil), Esto (Israel), Seroplex, Elicea, Lexamil, Lexam, Entact (Greece), Losita (Bangladesh), Reposil (Chile), Animaxen (Colombia), Esitalo (Australia), Lexamil (South Africa) | Antidepressant, SSRI | Depression (major), anxiety disorders | LINK | |
| Esomeprazole | Nexium, Nexum and others | Proton Pump Inhibitor | Gastric hyperacidity, GERD | LINK | |
| Ezogabine (Retigabine) | Potiga, Trobalt | Anticonvulsant | Seizures, Partial | LINK | |
| Famotidine | Pepcid, Fluxid, Quamatel | H2-receptor antagonist | Gastric hyperacidity, GERD | LINK | |
| Felbamate | Felbatol | Anticonvulsant | Epilepsy | LINK | |
| Fenfluramine (Removed from Market) | Pondimin, Ponderax, Adafax | Appetite suppressant | Obesity | LINK | |
| Fingolimod | Gilenya | Sphingosine phospate receptor modulator | Multiple Sclerosis | LINK | |
| Flecainide | Tambocor, Almarytm, Apocard, Ecrinal, Flécaine | Antiarrhythmic | Abnormal heart rhythm | LINK | |
| Fluconazole | Diflucan, Trican | Antifungal | Fungal infection | LINK | |
| Fluorouracil (5-FU) | Adrucil, Carac, Efudex, Efudix, others | Anti-cancer | Cancer | LINK | |
| Fluoxetine | Prozac, Sarafem, Fontex | Antidepressant, SSRI | Depression | LINK | |
| Flupentixol (Only on Non US Market) | Depixol, Fluanxol | Dopamine 2 and 5HT2a antagonist | Schizophrenia | LINK | |
| Fluvoxamine | Faverin, Fevarin, Floxyfral, Dumyrox and Luvox | Selective Serotonin Reuptake Inhibitor | Depression, Obsessive Compulsive Disorder | LINK | |
| Formoterol | Foradil, Foradile, Oxeze, Oxis, Atock, Atimos, Atimos Modulite, Perforomist, Dulera, Symbicort, Vannair, Quikhale FB | Bronchodilator | Asthma | LINK | |
| Furosemide (frusemide) | Lasix, Fusid, Frumex | Diuretic | Hypertension, diuresis | LINK | |
| Galantamine | Reminyl, Nivalin, Razadyne-ER, Lycoremine | Cholinesterase inhibitor | Dementia (Alzheimer's Disease) | LINK | |
| Garenoxacin (Only on Non US Market) | Geninax | Antibiotic | Bacterial infection | LINK | |
| Gatifloxacin (Removed from Market) | Tequin | Antibiotic | Bacterial infection | LINK | |
| Gemifloxacin | Factive | Antibiotic | Bacterial infection | LINK | |
| Granisetron | Kytril, Sancuso, Granisol | Antiemetic | Nausea, vomiting | LINK | |
| Grepafloxacin (Removed from Market) | Raxar | Antibiotic | Bacterial infection | LINK | |
| Halofantrine (Only on Non US Market) | Halfan | Antimalarial | Malaria | LINK | |
| Haloperidol | Haldol (US & UK), Aloperidin, Bioperidolo, Brotopon, Dozic, Duraperidol (Germany), Einalon S, Eukystol, Halosten, Keselan, Linton, Peluces, Serenace, Serenase, Sigaperidol | Antipsychotic | Schizophrenia, agitation | LINK | |
| Hydrochlorothiazide | Apo-Hydro, Aquazide H, BP Zide, Dichlotride, Hydrodiuril, HydroSaluric, Hydrochlorot, Microzide, Esidrex, Oretic | Diuretic | Hypertension, diuresis | LINK | |
| Hydrocodone - ER | Hysingla™ ER, Zohydro ER | Analgesic | Pain, severe | LINK | |
| Hydroxychloroquine | Plaquenil, Quineprox | Antimalarial, Anti-inflammatory | Malaria, SLE, rheumatoid arthritis | LINK | |
| Hydroxyzine | Atarax, Vistaril, Aterax, Alamon, Durrax, Equipose, Masmoran, Orgatrax, Paxistil Quiess, Tran-Q, Tranquizine | Antihistamine | Allergic reaction, anxiety disorders | LINK | |
| Ibogaine (Only on Non US Market) | None | Psychedelic | Narcotic addiction, unproven | LINK | |
| Ibutilide | Corvert | Antiarrhythmic | Abnormal heart rhythm | LINK | |
| Iloperidone | Fanapt, Fanapta, Zomaril | Antipsychotic, atypical | Schizophrenia | LINK | |
| Imipramine (melipramine) | Tofranil | Antidepressant, Tricyclic | Depression | LINK | |
| Indacaterol | Arcapta Neohaler (US), Onbrez Breezhaler (Canada), Utibron (combo w/ glycopyrrolate) | Bronchodilator | Chronic obstructive lung disease | LINK | |
| Indapamide | Lozol, Natrilix, Insig | Diuretic | Hypertension, diuresis | LINK | |
| Inotuzumab ozogamicin | Besponsa | Antineoplastic Agent | Acute Lymphocytic Leukemia | LINK | |
| Isoproterenol | Medihaler-Iso, Isuprel | Bronchodilator | Allergic reaction | LINK | |
| Isradipine | Dynacirc | Antihypertensive | Hypertension | LINK | |
| Itraconazole | Sporanox, Onmel | Antifungal | Fungal infection | LINK | |
| Ivabradine | Procoralan, Coralan, Corlentor, Coraxan, Ivabid, Bradia | Antianginal | Angina Pectoris (heart pain) | LINK | |
| Ketanserin (Only on Non US Market) | Sufrexal | Antihypertensive | Hypertension | LINK | |
| Ketoconazole | Nizoral, Sebizole, Ketomed, Keton | Antifungal | Fungal infection | LINK | |
| Lansoprazole | Prevacid | Proton Pump Inhibitor | Proton-pump inhibitor | LINK | |
| Lapatinib | Tykerb, Tyverb | Kinase inhibitor | Cancer (breast, metastatic) | LINK | |
| Lenvatinib | Lenvima | Anticancer | Cancer (Thyroid) | LINK | |
| Leuprolide | Lupron, Eligard, Viadur, Carcinil, Enanton, Leuplin, Lucrin, Procren, Prostap and others | Gonadotropin receptor agonist/antogist | Cancer (prostate) | LINK | |
| Levalbuterol (levsalbutamol) | Xopenex, Levolin, Axazest | Bronchodilator | Asthma | LINK | |
| Levofloxacin | Levaquin, Tavanic | Antibiotic | Bacterial infection | LINK | |
| Levomepromazine (methotrimeprazine) (Only on Non US Market) | Nosinan, Nozinan, Levoprome | Antipsychotic | Schizophrenia | LINK | |
| Levomethadyl acetate (Removed from Market) | Orlaam | Opioid agonist | Narcotic dependence | LINK | |
| Levosulpiride (Only on Non US Market) | Lesuride, Levazeo, Enliva (with rabeprazole) | Antipsychotic | Schizophrenia | LINK | |
| Lisdexamfetamine | Vyvanse | CNS stimulant | ADHD | LINK | |
| Lithium | Eskalith, Lithobid | Antimania | Bipolar disorder | LINK | |
| Loperamide | Imodium and many other OTC and Rx brands | Opiate | Diarrhea | LINK | |
| Lopinavir and ritonavir | Kaletra, Aluvia | Viral protease inhibitor | HIV/AIDS | LINK | |
| Melperone (Only on Non US Market) | Bunil, Buronil, Eunerpan | Antipsychotic, atypical | Schizophrenia | LINK | |
| Mesoridazine (Removed from Market) | Serentil | Antipsychotic | Schizophrenia | LINK | |
| Metaproterenol (orciprenaline) | Metaprel, Alupent | Bronchodilator | Asthma | LINK | |
| Methadone | Dolophine, Symoron, Amidone, Methadose, Physeptone, Heptadon | Opioid agonist | Narcotic dependence, pain | LINK | |
| Methamphetamine (Metamfetamine) | Desoxyn, Pervitin, Anadrex, Methedrine, Syndrox | CNS stimulant | Obesity, ADHD | LINK | |
| Methylphenidate | Ritalin, Concerta, Focalin, Daytrana, Methylin, Metadate CD | CNS stimulant | ADHD | LINK | |
| Metoclopramide | Reglan, Afipran, Maxolon, Cerucal, Clopamon, Clopra, Maxeran, Maxolon, Metozolv, Plasil, Pramin, Primperan, Perinorm | Antiemetic | Nausea, vomiting | LINK | |
| Metronidazole | Flagyl and many others | Antibiotic | Trichomoniasis, amebiasis, bacterial infection | LINK | |
| Midodrine | ProAmatine, Amatine, Gutron | Vasoconstrictor | Hypotension | LINK | |
| Midostaurin | Rydapt | Anti-cancer | Acute myeloid leukemia | LINK | |
| Mifepristone | Korlym, Mifeprex | Progesterone antagonist | Pregnancy termination | LINK | |
| Mirabegron | Myrbetriq | Beta3 adrenergic antagonist | Bladder spasm | LINK | |
| Mirtazapine | Remeron | Antidepressant, Tetracyclic | Depression | LINK | |
| Moexipril/HCTZ | Uniretic, Univasc | Antihypertensive | Hypertension | LINK | |
| Moxifloxacin | Avelox, Avalox, Avelon | Antibiotic | Bacterial infection | LINK | |
| Necitumumab | Portrazza | Anti-cancer | Lung Cancer | LINK | |
| Nelfinavir | Viracept | Antiviral | Viral infection (HIV/AIDS) | LINK | |
| Nicardipine | Cardene | Antihypertensive | Hypertension | LINK | |
| Nilotinib | Tasigna | Kinase inhibitor | Cancer (leukemia) | LINK | |
| Norepinephrine | Levophed | Vasconstrictor, Inotrope | Heart failure, shock (low blood pressure) | LINK | |
| Norfloxacin | Noroxin, Ambigram | Antibiotic | Bacterial infection | LINK | |
| Nortriptyline | Pamelor, Sensoval, Aventyl, Norpress, Allegron, Noritren, Nortrilen | Antidepressant, Tricyclic | Depression | LINK | |
| Nusinersen | Spinraza | Antisense oligonucleotide | Spinal Muscular Atrophy | LINK | |
| Ofloxacin | Floxin | Antibiotic | Bacterial infection | LINK | |
| Olanzapine | Zyprexa, Zydis, Relprevv | Antipsychotic, atypical | Schizophrenia, bipolar disorder | LINK | |
| Olodaterol | Striverdi Respimat | Bronchodilator | Asthma | LINK | |
| Omeprazole | Losec, Prilosec, Zegerid | Proton Pump Inhibitor | Gastric hyperacidity, GERD | LINK | |
| Ondansetron | Zofran, Anset, Ondemet, Zuplenz, Emetron, Ondavell, Emeset, Ondisolv, Setronax | Antiemetic | Nausea, vomiting | LINK | |
| Osimertinib | Tagrisso | Tyrosine kinase inhibitor | Cancer (EGFR pos. NSC Lung cancer) | LINK | |
| Oxaliplatin | Eloxatin | Antineoplastic Agent | Cancer | LINK | |
| Oxytocin | Pitocin, Syntocinon | Oxytocic | Labor stimulation | LINK | |
| Paliperidone | Invega, Xepilon | Antipsychotic, atypical | Schizophrenia | LINK | |
| Palonosetron | Aloxi | Antiemetic | Nausea | LINK | |
| Panobinostat | Farydak | Histone deacetylase inhibitor | Multiple myeloma (Part of a 3 drug regimen) | LINK | |
| Pantoprazole | Protonix and others | Proton Pump Inhibitor | Gastric hyperacidity, GERD | LINK | |
| Papaverine HCl (Intra-coronary) | none | Vasodilator, Coronary | Diagnostic adjunct | LINK | |
| Paroxetine | Paxil, Aropax, Pexeva, Seroxat, Sereupin, Seroxat | Antidepressant, SSRI | Depression | LINK | |
| Pasireotide | Signifor | Somatostatin analog | Cushings Disease | LINK | |
| Pazopanib | Votrient | Tyrosine kinase inhibitor | Cancer (renal cell, sarcoma) | LINK | |
| Pentamidine | Pentam | Antifungal | Fungal infection (Pneumocystis pneumonia) | LINK | |
| Perflutren lipid microspheres | Definity, Optison | Imaging contrast agent | Echocardiography | LINK | |
| Perphenazine | Trilafon, Etrafon/Triavil, Decentan | Antipsychotic | Schizophrenia | LINK | |
| Phentermine | Adipex P, Adiphene (India), Anoxine-AM, Ionamin, Duromine, Metermine, Miraprontv, Obephen, Obermine, Obestin-30, Phentremine, Phentrol, Phenterex, Phentromin, Pro-Fast SA, Redusa, Panbesy, Obenix, Oby-Trim, Teramine, Zantryl, Sinpet, Supremin, Suprenza, Umine, Weltmine | Appetite suppressant | Obesity | LINK | |
| Phenylephrine | Neosynephrine | Vasoconstrictor | Shock (low blood pressure), allergic rhinitis, asthma | LINK | |
| Phenylpropanolamine (Removed from Market) | Acutrim, Dexatrim | Appetite suppressant | Obesity | LINK | |
| Pilsicainide (Only on Non US Market) | Sunrythm | Anti-arrhythmic | Arrhythmia | LINK | |
| Pimavanserin | Nuplazid | Antipsychotic, atypical | Psychosis, Parkinson's Disease | LINK | |
| Pimozide | Orap | Antipsychotic | Tourette's Disorder | LINK | |
| Pipamperone (Only on Non US Market) | Dipiperon (E.U), Propitan (Japan), Dipiperal, Piperonil, Piperonyl | Antipsychotic | Schizophrenia | LINK | |
| Piperacillin/Tazobactam | Tazosyn and Zosyn | Antibacterial | Bacterial infection | LINK | |
| Posaconazole | Noxafil, Posamol | Antifungal | Fungal infection | LINK | |
| Primaquine phosphate | Anti-malarial | Malaria | LINK | | |
| Probucol (Removed from Market) | Lorelco | Antilipemic | Hypercholesterolemia | LINK | |
| Procainamide | Pronestyl, Procan | Antiarrhythmic | Abnormal heart rhythm | LINK | |
| Promethazine | Phenergan | Antipsychotic / Antiemetic | Nausea, vomiting | LINK | |
| Propofol | Diprivan, Propoven | Anesthetic, general | Anesthesia | LINK | |
| Prothipendyl (Only on Non US Market) | Dominal, Largophren, Timoval, Timovan, Tumovan | Antipsychotic | Schizophrenia | LINK | |
| Pseudoephedrine | PediaCare, Sudafed | Decongestant | Allergic reaction, allergic rhinitis, asthma | LINK | |
| Quetiapine | Seroquel | Antipsychotic, atypical | Schizophrenia | LINK | |
| Quinidine | Quinaglute, Duraquin, Quinact, Quinidex, Cin-Quin, Quinora | Antiarrhythmic | Abnormal heart rhythm | LINK | |
| Quinine sulfate | Qualaquin | Antimalarial | Malaria, leg cramps | LINK | |
| Ranolazine | Ranexa, Ranozex | Antianginal | Angina Pectoris (heart pain) | LINK | |
| Ribociclib | Kisqali | Cyclin Dependent Kinase inhibitor | Breast Cancer | LINK | |
| Rilpivirine | Edurant, Complera, Eviplera | Antiviral | Viral infection (HIV/AIDS) | LINK | |
| Risperidone | Risperdal | Antipsychotic, atypical | Schizophrenia | LINK | |
| Ritodrine (Removed from Market) | Yutopar | Muscle relaxant | Premature labor | LINK | |
| Romidepsin | Istodax | Histone deacetylase inhibitor | Lymphoma | LINK | |
| Roxithromycin (Only on Non US Market) | Rulide, Xthrocin, Roxl-150, Roxo, Surlid, Rulide, Biaxsig, Roxar, Roximycinv, Roxomycin, Rulid, Tirabicin, Coroxin | Antibiotic | Bacterial infection | LINK | |
| Salmeterol | Serevent, Advair | Bronchodilator | Asthma | LINK | |
| Saquinavir | Invirase(combo) | Antiviral | Viral infection (HIV/AIDS) | LINK | |
| Sertindole (Only on Non US Market) | Serdolect, Serlect | Antipsychotic, atypical | Schizophrenia, anxiety | LINK | |
| Sertraline | Zoloft, Lustral, Daxid, Altruline, Besitran, Deprax, Elrval, Emergen, Gladem, Implicane, Sedoran, Sealdin, SerivoLowfin, Stimuloton, Tresleen, Sertralin Bluefish | Antidepressant, SSRI | Depression | LINK | |
| Sevoflurane | Ultane, Sojourn | Anesthetic, general | Anesthesia | LINK | |
| Sibutramine (Removed from Market) | Meridia | Appetite suppressant | Obesity | LINK | |
| Solifenacin | Vesicare | Muscle relaxant | Bladder spasm | LINK | |
| Sorafenib | Nexavar | Tyrosine kinase inhibitor | Cancer (liver, renal cell, metastatic thyroid) | LINK | |
| Sotalol | Betapace, Sotalex, Sotacor | Antiarrhythmic | Abnormal heart rhythm | LINK | |
| Sparfloxacin (Removed from Market) | Zagam | Antibiotic | Bacterial infection | LINK | |
| Sulpiride (Only on Non US Market) | Dogmatil, Dolmatil, Eglonyl, Espiride, Modal, Sulpor | Antipsychotic, atypical | Schizophrenia | LINK | |
| Sultopride (Only on Non US Market) | Barnetil, Barnotil, Topral | Antipsychotic, atypical | Schizophrenia | LINK | |
| Sunitinib | Sutent | Kinase inhibitor | Cancer (GIST, renal cell, pNET) | LINK | |
| Tacrolimus | Prograf, Prograf, Advagraf, Protopic | Immunosuppressant | Immune suppression | LINK | |
| Tamoxifen | Nolvadex(discontinued 6/13), Istubal, Valodex | Anticancer | Cancer (breast) | LINK | |
| Telaprevir | Incivo, Incivek | Antiviral | Viral infection (hepatitis C) | LINK | |
| Telavancin | Vibativ | Antibiotic | Bacterial infection | LINK | |
| Telithromycin | Ketek | Antibiotic | Bacterial infection | LINK | |
| Terbutaline | Brethine, Bricanyl, Brethaire, Terbulin | Bronchodilator | Asthma, premature labor | LINK | |
| Terfenadine (Removed from Market) | Seldane | Antihistamine | Allergic rhinitis | LINK | |
| Terlipressin (Only on Non US Market) | Teripress, Glypressin, Terlipin, Remestyp, Tresil, Teriss and others | Vasoconstrictor | Septic shock | LINK | |
| Terodiline (Only on Non US Market) | Micturin, Mictrol (not bethanechol) | Muscle relaxant | Bladder spasm | LINK | |
| Tetrabenazine | Nitoman, Xenazine | Vesicular Monoamine Transporter 2 Inhibitor | Chorea (Huntington's disease) | LINK | |
| Thioridazine | Mellaril, Novoridazine, Thioril | Antipsychotic | Schizophrenia | LINK | |
| Tiapride (Only on Non US Market) | Tiapridal, Italprid, Sereprile, Tialaread, Tiaryl, Tiaprim, Tiaprizal, Sereprid, Tiapridex | Selective D2, D3 dopamine antagonist | Alcoholism, withdrawal | LINK | |
| Tipiracil and Trifluridine | Lonsurf | Anti-cancer | Metastatic colorectal cancer | LINK | |
| Tizanidine | Zanaflex, Sirdalud | Muscle relaxant | Muscle spasticity | LINK | |
| Tolterodine | Detrol, Detrusitol | Muscle relaxant | Bladder spasm | LINK | |
| Toremifene | Fareston | Estrogen agonist/antagonist | Cancer (breast, metastatic) | LINK | |
| torsemide (torasemide) | Demadex, Diuver, Examide | Diuretic | Hypertension, diuresis | LINK | |
| Trazodone | Desyrel (discontinued 6/13), Oleptro, Beneficat, Deprax, Desirel, Molipaxin, Thombran, Trazorel, Trialodine, Trittico, Mesyrel | Antidepressant, SARI | Depression, insomnia | LINK | |
| Trimethoprim-Sulfamethoxazole | Septra, Bactrim, Sulfatrim, Biseptol, Co-trimoxazole, Cotrim, Septrin, Trisul | Antibiotic | Bacterial infection | LINK | |
| Trimipramine | Surmontil, Rhotrimine, Stangyl | Antidepressant, Tricyclic | Depression | LINK | |
| Tropisetron (Only on Non US Market) | Navoban, Setrovel | Antiemetic | Nausea, vomiting | LINK | |
| Valbenazine | Ingrezza | Vesicular monamine transporter 2 inhibitor | Tardive Dyskinesia | LINK | |
| Vandetanib | Caprelsa | Anticancer | Cancer (thyroid) | LINK | |
| Vardenafil | Levitra | Phosphodiesterase 5 inhibitor | Erectile dysfunction | LINK | |
| Vemurafenib | Zelboraf | Kinase inhibitor | Cancer (melanoma) | LINK | |
| Venlafaxine | Effexor, Efexor | Antidepressant, SNRI | Depression | LINK | |
| Vilanterol/fluticasone furoate | Breo Ellipta | Bronchodilator | Asthma | LINK | |
| Voriconazole | VFend | Antifungal | Fungal infection | LINK | |
| Vorinostat | Zolinza | Histone deacetylase inhibitor | Cancer (lymphoma) | LINK | |
| Ziprasidone | Geodon, Zeldox | Antipsychotic, atypical | Schizophrenia | LINK | |
| Zotepine (Only on Non US Market) | Losizopilon, Lodopin, Setous and Zoleptil | Antipsychotic, atypical | Schizophrenia | LINK | |
Known Risk of TdPPossible Risk of TdPConditional Risk of TdPDrugs to Avoid in Congenital Long QT